A Gonadotropin-releasing Hormone-binding Inhibitor from Bovine Ovaries
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چکیده
منابع مشابه
A gonadotropin-releasing hormone-binding inhibitor from bovine ovaries. Purification and identification as histone H2A.
Bovine, ovine, rat, and human ovaries contain a protein defined as gonadotropin-releasing hormone (GnRH)-like because it reversibly inhibits the high affinity binding of GnRH to rat ovarian membranes, but these same tissues contain little, if any, detectable GnRH. In the present study this GnRH-binding inhibitor (GnRH-BI) was purified from bovine ovaries by a combination of reversed-phase high ...
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A gonadotropin-releasing hormone (GnRH)-binding inhibitor (GnRH-BI) was purified from bovine ovaries and identified as histone H2A. In the present studies, the biological effects of partially purified and purified ovarian GnRH-BI, as well as calf thymus histone H2A, were examined in rat ovarian cells. Since GnRH has direct antigonadotropic actions on these cells, the effects on luteinizing horm...
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Gonadotropin-releasing hormone (GnRH) regulates reproduction. The human GnRH receptor lacks a cytoplasmic carboxy-terminal tail but has amino acid sequence motifs characteristic of rhodopsin-like, class A, G protein-coupled receptors (GPCRs). This review will consider how recent descriptions of X-ray crystallographic structures of GPCRs in inactive and active conformations may contribute to und...
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Serum LH concentrations were less than 1 ng/ml immediately prior to castration of four 5-month-old Holstein bulls. A significant increase occurred 7 hr post-castration and serum LH remained elevated thereafter, interspersed with non-rhythmic episodic fluctuations of this gonadotropin. Single injections of testosterone or dihydrotestosterone, given iv or im, did not depress post-castration serum...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)60427-2